Dimethylthiourea, an oxygen radical scavenger, protects isolated cardiac myocytes from hypoxic injury by inhibition of Na(+)-Ca2+ exchange and not by its antioxidant effects.
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منابع مشابه
Oxygen Radical Scavenger, Protects Isolated Cardiac Myocytes From Hypoxic Injury by Inhibition of Na+-Ca21 Exchange and Not by Its Antioxidant Effects
mm Hg) glucose-free buffer alone (n=50) or with the addition of the oxygen radical scavengers 1,3-dimethyl-2-thiourea (DMTU, 25 mM, n=46), human recombinant superoxide dismutase (SOD, 1,000 units/ml, n=40), or the combination of these agents (n=41). All cells responded by undergoing contracture to a rigor form. Hypoxia was then continued for a second period (T2), the duration of which correlate...
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The membrane lipid environment and lipid signaling pathways are potentially involved in the modulation of the activity of the cardiac Na-Ca exchanger (NCX). In the present study biophysical mechanisms of interactions of amphiphiles with the NCX and the functional consequences were examined. For this purpose, intracellular Ca concentration jumps were generated by laser-flash photolysis of caged ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1992
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.70.4.804